Desktop and Enterprise Software, Solutions and Services for Chemists and Biologists.

Desktop Support » Compatibility Notes


Desktop v14 Release

Please review the ChemBioOffice Release Notes document for compatibility issues on Windows and Mac platforms.

Please note that only the 32-bit Office 2013 version is supported.

Section 6 lists the known issues and workarounds.

MS Office 2010

Version 13 supports MS Office 2010 (32-bit) documents. Older versions have known limitations:

We have tested our 12.0 software with MS Office 2010 (32-bit only) and have found that ChemBioOffice 12.0/2010 works with Microsoft Office 2010 with the following exceptions: ChemDraw for Excel requires version 12.0.2, available from the Support Downloads page for our 12.0 customers. E-Notebook does not support MS Office 2010 documents, we plan to address that issue in a future release. There are issues with copying and pasting between Microsoft Office 2010 and other software programs, including ChemBioDraw and ChemBio3D, that have been fixed by Microsoft in hotfixes. Please make sure you have applied the latest Microsoft hotfixes if you are seeing problems with compatibility with our applications.

Windows 7

Version 12.0 has been tested with Windows 7 Professional (32 bit) and Windows 7 Ultimate (32 bit). Except for BioAssay and STATISTICA, we found no compatibility problem with version 12.0 applications. We support the use of those operating systems as a client system. BioAssay and STATISTICA are the only application that's not supported under Windows 7 at this time.

We have also tested our version 12.0 software with Windows 7 SP1 (32 and 64-bit). We have found that there are no problems with the compatibility besides BioAssay and STATISTICA.

Windows 8

Initial testing has shown that there are no compatibility problems between ChemBioDraw, ChemBio3D and ChemBioFinder. Testing is ongoing between the E-Notebook and Inventory applications.

We hope to be able to provide full support for the operating system in the near future, but currently the Windows 8 OS is not officially supported.

Please continue to check our System Requirements page for any updates.

64-bit Windows

Windows 7 Professional, Ultimate (64 bit), and Enterprise (64 bit) are now supported with the following caveats:

1. NOT supported for BioAssay

2. 64-bit IE is not supported for Chemdraw and Chem3D controls, only 32-bit IE is.

3. The SQL Server Express installer that ships with our 2010 release is the 32-bit version. Customers who want to run on a 64-bit system will need to instead run the 64-bit version, with the appropriate settings

No other 64-bit versions of Windows have been tested and are therefore not supported.

MS Office 2007

The current version is compatible with MS Office 2007.

Versions of our software prior to 12.0 were developed and released well before MS Office 2007, therefore prior to 12.0 are not compatible with MS Office 2007 applications.

Windows 2000

The latest versions of our software have been tested and work with Windows 2000 (Not supported for E-Notebook). Versions of our software prior to 6.0 are not supported under Windows 2000, but we are also not aware of any conflicts with most older versions of our software and Windows 2000. We do know that the following software is not compatible with Windows 2000: ChemDraw 3.1, ChemOffice WebServer, and ChemOffice Ltd 3.1 or lower.

Windows XP

The latest versions of our software install and run under Windows XP (32 bit only; XP Home is not supported). Versions of our software prior to 7.0 are not compatible with Windows XP.

Windows Vista

The latest versions of our Desktop software install and run under Windows Vista (32-bit only; Vista Home/Home Premium are not supported). Versions of our software prior to 11.0 are not compatible with Windows Vista.

Czech Windows XP

Versions of ChemDraw prior to 11.0.1 will crash when launched under the Czech version of Windows XP. The 11.0.1 update is available to 11.0 users from the Support Downloads page.

MS Office 2003

The current version is compatible with MS Office 2003. Versions of our software prior to 9.0 were developed and released well before MS Office 2003. Versions 8.0 or less cannot install our Add-Ins to Microsoft Office 2003. Prior to 9.0, the CombiChem and Purchasing for Excel Add-Ins and our Word Add-Ins were not compatible with MS Office 2003. It is possible to get the 8.0 ChemDraw and ChemSAR for Excel Add-Ins working with MS Office 2003. Please see this tech note for details.

Copying and pasting into MS Office 2003 applications and OLE Editing appear to work when using our 8.0 software.

MS Office XP (2002)

With the release of ChemOffice 2002 (version 7.0), our Word and Excel Add-Ins will now install and work with Microsoft Office XP. Versions prior to the 7.0 release are not compatible with Office XP. ChemOffice Ultra users please note that BioAssay Manager is only compatible with Microsoft Office 2000.

Internet Explorer 5.5 SP2-6.0

Microsoft Internet Explorer Service Pack 2 (5.5 SP2) and above, no longer support the Netscape Plugin architecture. According to Microsoft, future releases of Internet Explorer will also not support old plugins. Therefore ChemDraw 6.x and below and Chem3D 4.x and below Plugins are no longer compatible with IE 5.5 SP2 and above.

The latest ChemDraw Plugin 8.0 is compatible with IE 5.0 and above. The latest Chem3D Net plugin, v6.0.1, which is now available from our support downloads page as well as part of the ChemOffice Plugin, is also compatible.

Netscape for Windows

The latest ChemDraw Plugin (Windows) is compatible with Netscape 6.2.x -7.0.x. The latest ChemOffice Plugin, which installs both the ChemDraw and Chem3D Plugin is compatible with Netscape 6.2.x -7.0.x.

Windows Millennium (Windows Me)

The latest versions of our software no longer support Windows Me. The last version to support Windows Me was version 8.0. We are aware of one problem with an older version of ChemFinder and Windows Me. There is a problem with updating the structure field in ChemFinder 5.1.2 and below. This problem was fixed in version 6, 7, and 8.

Gaussian 03W C.02

Chem3D cannot link with G03W C.02. Gaussian has removed the way Chem3D links to Gaussian (via the GXX-Exec.Dat file). We hope to address this Gaussian change in a future update of Chem3D.

Windows XP SP2

Windows XP Service Pack 2 includes security features that automatically block active content. This means that by default, Internet Explorer blocks ChemDraw and Chem3D ActiveX controls. To activate them, you must choose the option to "Allow Blocked Content" from the "Information bar" appearing under the Address bar notifying you that the security settings have blocked some of the content of the page. See this example picture for details.

IE does not remember this information, so you must repeat the activation each time you access the page.


Desktop v14 Release

Please review the ChemBioOffice Release Notes document for compatibility issues on Windows and Mac platforms.

Section 6 lists the known issues and workarounds.

Mac OS X 10.7 LION

ChemDraw 12.0.3 was developed and released prior to MacOS 10.7, however, it is officially supported under MacOS 10.7. But, there are known features that will not work and are not supported.

  • The ChemDraw Plugin does not work under Safari 5.x.
  • ChemDraw remembers and reopens the last viewed/worked documents when relaunched after quitting the application.
  • Multi-colored non-structure objects in a document turn to Black & White when applying document settings from another style sheet without opting to modify existing objects.
  • Online menu items to ChemACX do not work.

Versions earlier than 12.0.3 are not supported on MacOS 10.7.

MS Office 2008 & iWork

Updated 11/17/2010

Microsoft has released an update to Microsoft Office 2011 labeled 14.0.1 that now supports round trip editing of ChemDraw 12.0.2 structures.

When copying a structure in ChemDraw 12.0.1 and below, the ChemDraw application would put a PICT of the image on the clipboard. We embedded chemical information into the PICT image, so that when that PICT image was transferred back into ChemDraw, the ChemDraw application would be able to interpret the picture as a chemically meaningful object that could be edited by ChemDraw. Due to continued modernizations in the Mac OS, newer applications are no longer supporting the PICT format on the clipboard. In newer applications, the use of PDFs to transfer copied images is now what is expected. This is why round trip editing between ChemDraw 12.0.1 and below and MS Office 2008 applications as well as iWork applications ceased to work.

CambridgeSoft has made changes to ChemDraw 12.0.2, so that instead of only using the now unsupported PICT format, we also place the chemical information into the PDF that gets placed on the clipboard when copying a structure in ChemDraw. The application that this PDF gets pasted into now needs to handle the PDF correctly, such that the chemical information is not stripped. Apple has this working with the latest version of Keynote. They are working towards getting the other iWork applications to also support the expected PDF with the chemical information, so round trip editing can happen in more than Keynote. Microsoft has released an update to Microsoft Office 2011 labeled 14.0.1 that now supports round trip editing of ChemDraw 12.0.2 structures. This means that documents created in Microsoft Office 14.0.1 and ChemDraw 12.0.2 now support copying the structure out of the Microsoft Office document, pasting it into ChemDraw 12.0.2 and editing it. Note: you must have the “Add PDF to Clipboard” preference checked in ChemDraw for this to work with Microsoft Office 14.0.1. It is checked by default in ChemDraw 12.0.2.

Currently the chemical information is being stripped from the PDF by Microsoft Office 2008 applications, such that what remains is just a picture, and not something that can be edited by ChemDraw. There are no Microsoft Office 2008 patches planned to address this issue. If you have Microsoft Office 2008 Mac documents and open them in the current version of Microsoft Office for the Mac, you will find that the structures still cannot be edited (they are just pictures) for the reasons above. You will find the same problem if you try to transfer a Microsoft Office 2008 document to Windows or if you open any Windows Microsoft Office document in Microsoft Office 2008 or above for the Mac.

If you have Microsoft Office 2004 documents which do enable you to cut the pictures out and edit them in ChemDraw and you open them in the current version of Microsoft Office for the Mac, you will find that the structures can no longer be edited. Users of Microsoft Office 2004 for the Mac will need to transfer the structures into ChemDraw, and then copy and paste them from ChemDraw 12.0.2 to Microsoft Office 14.0.1 or redraw the structure in ChemDraw and then copy and paste into Microsoft Office 14.0.1.

Mac OS X 10.5 Leopard

Versions prior to the 11.0.1 update are not supported under MacOS 10.5. 11.0 users can download the latest version from the Support download site. If you have version 10 or less, please upgrade to the latest version.

Mac OS X 10.6 Snow Leopard

Version 12.0.2 (available from the Download page) has been qualified and is now supported under MacOS 10.6. Versions prior to 12.0.2 are not compatible with MacOS 10.6.

Intel Macs/Universal Binaries

The 11.0 and above goods are universal binaries, so we natively support Intel Mac (we also still natively support PowerPC as both basically are in the universal binary and the OS decides which one it will use).

Please note that the installer that puts the goods on the system is not a universal binary. This really should not cause any problems for most users as it is completely transparent. However, there are tools that can remove all PowerPC related code including the Rosetta translator from Intel Macs to save disk space. Since the installer will need some of this PowerPC related code, it won’t install. It bounces in the dock and then just goes away and nothing happens. If you experience this problem, you can reinstall the PowerPC framework (from the Apple OS DVD) and all should work.

Safari 3

Versions prior to the 11.0.1 update are not compatible with Safari 3.0. Please download the latest Plugin (or if you have an application, download the latest application which includes your Plugin) from the Support download site.

Mozilla, FireFox and Netscape for Mac

The latest version of our Plugin supports Netscape 7.0.x, Mozilla 1.7.5 and above, and, FireFox 1.x

For users who have older versions of our Plugin, here is what we know:

MacOS X builds of Netscape 7.0 are required for the 10.0 version of the ChemDraw Plugin. Please note that MacOS X builds of Netscape 7.0 will run under MacOS 9.

With the release of the 9.0.1 update (available from the support download page) Mozilla 1.7.5 and above and FireFox 1.0.x and above on Mac OS X are supported.

The original 8.0 ChemDraw Plugin will crash Netscape 7.0 and Mozilla. Download the latest 8.0.x Plugin from our support download page.

Old Macintosh Application Issues

MacOS 9 and Chem3D 5.0 and less - Chem3D cannot save in the native Chem3D format under MacOS9. See the Chem3D Save FAQ for solution.

The Apple Navigation system extension can cause problems opening and saving files when opening from Windows disks. If you remove the extension the problem will not occur. See the Chem3D ReadMe file for full details.

The Minimize energy command in Chem3D 4.0 hangs Chem3D under MacOS 8.5. The workaround is to choose Molecular Dynamics or Compute Properties from the MM2 menu and then change the Job Type under the Job Type tab to Minimize Energy. The problem has also been fixed in Chem3D 5.0.

CS Chem3D version 3.1.2 or earlier running on a PowerPC with Modern Memory Manager turned On. Contact to order the latest version of Chem3D, which is Power Mac native or Chem3D Plus 3.1 users can download a non-Power Mac native patch (version 3.1.3) here for free.

CS ChemDraw 2.1.3 and LaserWriter 8 printer driver. Update to the latest version of ChemDraw or use an older printer driver version.

CS ChemFinder 1.0 is incompatible with System 7.1. Update to the latest version of ChemFinder.


Hardware Compatibility Issues

We are not aware of any hardware compatibility issues with the latest versions of our software on any platform.